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What vitamins or supplements do you take on a daily basis?

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Wild at Heart
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pussy, wine, ass 'n' weed all a *against lush guidelines* needs.
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I take Special Two vitamins, twice a day, made by NOW. They do me a world of good, more energy, better health-I'd recommend them to anybody
Active Ink Slinger
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I used to take a ton of supplements, 40 per day, but on advice of my personal, live-in physician I stopped. I now only take a mulit vitamin and an Iron supplement.
Lurker
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I take a multivitamin for just basic things and I take a vitamin for hair/skin/nails
Site administrator
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A probiotic for my digestive system, a product called Nutricalm which I think is rather an all-in-1 and a large Omega-3 capsule.
Fancy Schmancy
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Multi-vitamin, plus additional D, B complex, Magnesium, Calcium, Iron, Co-Q 10, flaxseed oil, grapeseed extract and C. In terms of effects that I have actually noticed, the flaxseed oil appeared to alleviate dry eyes, the iron helped with fatigue and chronic anemia, and the magnesium seemed to reduce headaches. Anyway, works for me.
Active Ink Slinger
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Used to take a women's one a day multivitamin...now I drink Rockstar to get my daily amount of Taurine and all those other essential things to keep me ticking.
For generations our ancestors fought proudly as warriors against the Jedi. Reclaim our armored past for an unending future.
Active Ink Slinger
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Drink a shot of apple cider vinegar at night, plus other vitamins and supplements.
Cheeky Chick
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Flintstones's chewables.
"insensitive prick!" – Danielle Algo
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My brother in law has some neurological issues that, according to his physician, was most probably caused by too much B6 from multivitamin pills. He called the vitamin industry the biggest scam there is, because when you have a rather varied diet, which most people in the developed countries have, you'll get all the vitamins you need. Even processed foods often have vitamins and minerals added already. But if your diet is still not varied enough you better just add the specific vitamins you need instead of just all of them. For some vitamins, like vitamin C I believe, that may not be an issue as your body will get rid of any excess. But for others, like B6, it can definitely become an issue.


===  Not ALL LIVES MATTER until BLACK LIVES MATTER  ===

Lurker
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"vitamins, supplements, or exotic foods that are supposed to have special health benefits?"

I think "supposed to " is the most important part of that sentence.

Unless you are homeless, a drug addict, or have a crazy weird diet, you will not be deficient in any of the essential nutrients.

If you are concerned about nutrition I suggest you pick up a book on basic nutrition and learn the basics instead of spending money on stuff you don't need.





This is a university textbook, and thus will run you about 100 bucks. But it's actual science based information. Not garbage internet propaganda trying to sell you something.
Active Ink Slinger
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Multivitamin for women & fish oil

Brandie
"insensitive prick!" – Danielle Algo
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Quote by DamonX
Unless you are homeless, a drug addict, or have a crazy weird diet, you will not be deficient in any of the essential nutrients.


I guess that makes vegetarian/vegan diets crazy weird ;) #B12


===  Not ALL LIVES MATTER until BLACK LIVES MATTER  ===

Lurker
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Quote by noll


I guess that makes vegetarian/vegan diets crazy weird ;) #B12


Yeah. I consider vegans to have a weird diet. It's not natural when you take into account that for most of human history vegans would not have survived. Vegetarian is fine. As you so subtly hinted at, vitamin B12 only comes from animal sources. The people who think being a vegan is "natural" are probably the same ones spending 30 dollars a gallon for raw water.
Lurker
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Fish oil/omega 3 capsuals as well as vitaim c and muti vitamins gummies.
Lurker
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Quote by SilentBeauty
Fish oil/omega 3 capsuals as well as vitaim c and muti vitamins gummies.


Ok... So you are taking a multi vitamin which already has more vitamin C that any human being would ever need... So why are you taking extra vitamin C on top of that?

I'm just curious as to your reasoning.

Vitamin C (ascorbic acid) is a water soluble vitamin. That means it's not stored in your body. If you take more than you need, it's excreted in your urine. So essentially what you are doing is paying 20-30 dollars a month for bright orange colored pee.

Please explain...

In the meantime, I have some magic beans you might be interested in.
The Linebacker
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Quote by DamonX


Ok... So you are taking a multi vitamin which already has more vitamin C that any human being would ever need... So why are you taking extra vitamin C on top of that?

I'm just curious as to your reasoning.

Vitamin C (ascorbic acid) is a water soluble vitamin. That means it's not stored in your body. If you take more than you need, it's excreted in your urine. So essentially what you are doing is paying 20-30 dollars a month for bright orange colored pee.

Please explain...

In the meantime, I have some magic beans you might be interested in.


I'm thinking of marketing pee dye pills. All the colors of the rainbow. People could compare their pee colors at parties. I bet this could be more popular than alcohol enemas.
Lurker
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Chicken gizzards for B12
Lurker
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Quote by Buz


I'm thinking of marketing pee dye pills. All the colors of the rainbow. People could compare their pee colors at parties. I bet this could be more popular than alcohol enemas.


Hmmm.... I think if you found a way to color cum it might be more interesting. It might give "Rainbow parties" a whole new lease on life.


The Linebacker
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Many off brand vitamin makers create a product that can't even be absorbed correctly into the body.

But with this season's extreme flu epidemic, this strain being extra virilent, and my region especially hard hit, I have been taking an immune system boost.

Back when I was doing body building I did take protein supplements but finally came to the conclusion that those mostly make you fart a lot. That annoyance mostly striking during an important business meeting, a quiet intimate time on a date, or when the pastor would ask for a quiet moment of contemplation at church.
The Linebacker
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Quote by DamonX


Hmmm.... I think if you found a way to color cum it might be more interesting. It might give "Rainbow parties" a whole new lease on life.




Great idea! Now, a 2 flavor choice. Many great colors for cum, making for better bukkake parties, and colored pee for those hosting golden shower parties. Now we need an idea to colorize alcohol enema parties. I am feeling very capitalistic. Any investors?
Cryptic Vigilante
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Quote by DamonX
"vitamins, supplements, or exotic foods that are supposed to have special health benefits?"

I think "supposed to " is the most important part of that sentence.

Unless you are homeless, a drug addict, or have a crazy weird diet, you will not be deficient in any of the essential nutrients.

If you are concerned about nutrition I suggest you pick up a book on basic nutrition and learn the basics instead of spending money on stuff you don't need.

This is a university textbook, and thus will run you about 100 bucks. But it's actual science based information. Not garbage internet propaganda trying to sell you something.

Quote by DamonX
Ok... So you are taking a multi vitamin which already has more vitamin C that any human being would ever need... So why are you taking extra vitamin C on top of that?

I'm just curious as to your reasoning.

Vitamin C (ascorbic acid) is a water soluble vitamin. That means it's not stored in your body. If you take more than you need, it's excreted in your urine. So essentially what you are doing is paying 20-30 dollars a month for bright orange colored pee.

Please explain...

In the meantime, I have some magic beans you might be interested in.


I think it's important to differentiate between deficiencies, inadequacies and optimal health here. Actual deficiencies are when noticeable symptoms are observed due to low intakes of a certain vitamin; by contrast, inadequacies represent intakes that either put you at risk of developing such symptoms or where only minor/transient ones are present. Cases of advanced scurvy (ie. proper deficiencies) aren't all that frequent in this day and age, I'll grant you that much. However, here's a systematic evaluation of nutritional inadequacies in modern US:



Source: https://www.ars.usda.gov/ARSUserFiles/80400530/pdf/0102/usualintaketables2001-02.pdf


The requirements evaluated here (ie. Estimated Average Requirements) are actually extremely basic requirements: people who ingest exactly the prescribed quantities would still have a 50% chance to develop health issues. If you want the requirement which covers 97-98% of health risks, what you need is the RDI (ie. Recommended Dietary Intake), which is usually 25% higher than the EAR value. According to that and the diagram above, it's safe to assume that nearly 40% of Americans still don't get an adequate intake of vitamin C, while practically 99% of them don't get enough vitamin E. You know, modern Americans, the most well-fed population in the whole goddamn human history who even have a reputation for overeating. And we're not even talking about optimal health here, we're just talking about very basic nutritional adequacies (more about that distinction to follow).

Now let's take this a step further: let's talk about the heterogeneity of vitamins depending on each individual and how food charts really aren't as accurate as most people assume them to be concerning vitamins.

Different vitamins affect different people very differently, most researchers clearly mention that fact whenever discussing their effects: a dosage that's unproductive for certain people might be beneficial to others, while one that's beneficial for certain people might actually be detrimental to others (although vitamin C itself is hardly ever harmful, aside from gastric discomfort at megadoses). Just observe any graph representing the raise in blood plasma concentrations of different people ingesting a given dose of a vitamin: no two people ever show the exact same curves and it's been demonstrated time and again that bioavailability has an enormous personal component. And we're not even getting into how genetics/lifestyles can greatly influence which specific plasma concentration exactly will be required for you to cover your own basic needs, how easy it is for a vitamin to pass through cell membranes from an individual to the next, or how plasma concentration really isn't all that reliable to assess whole-body status of a vitamin anyway. As a side note, vitamin C (the oxidized form at least) actually competes against glucose for transport into the cells because they share the exact same proteins as transmembrane carriers (ie. GLUT1 and GLUT3). In that respect, it's highly conceivable that people eating low-to-moderate carb diets are much more likely to take full advantage of vitamin C than your average sugar-loving slacker.

Similarly, no two sources ever present the exact same quantities of vitamin C. And I’m not talking about comparing apples and oranges (literally in this case); I'm talking about comparing oranges to oranges. You may as well read that your daily orange provides 60mg of vitamin C on your favorite dietary website, but the reality is this:



Source: https://www.researchgate.net/publication/24430305_Vitamin_C_and_the_Role_of_Citrus_Juices_as_Functional_Food


See how the content of vitamin C varies so much? An orange doesn't provide exactly 60mg of vitamin C as you see on charts; it provides anywhere between 30mg and 80mg of it. There are even great variations within the exact same variety, depending on the producer. Fuck, pronounced variations even exist between oranges of the same goddamn tree, and I'm really not making this up. Ahh, but we're still comparing fresh oranges to fresh oranges, and an orange that's been sitting on your counter for a week can easily lose 50% of its vitamin C. Not to mention that fruits are still an easy case compared to vegetables that require cooking. Ascorbic acid has a reputation for being an extremely unstable molecule which can degrade at the mere presence of air or light: do you seriously believe that your pan-fried broccoli will contain as much vitamin C as advertised?

What I'm getting at is that approximately ingesting 90mg of vitamin C to cover your theoretical 90mg RDA really doesn't provide much guarantees: what you're really getting might only be 40mg, while your own individual needs might as well be 150mg. I'm really not advocating a 'more is better' approach here (not yet at least); I'm only suggesting that making goddamn sure to go past your daily needs is much more sound than hoping to match a volatile intake to a conservative requirement. And that's particularly true concerning health and considering that properly gauging one's diet is still a challenge for plenty of people. But hey, that certainly doesn't stop doctors and dieticians alike from clamoring that one average orange fully covers your daily needs in vitamin C, or for millions of people to buy right into their diploma-embellished ignorance.

Your friends invite you to a restaurant which supposedly charge $30 a meal: do you bring $30 or $40? Engineers design a plane which undergoes a force of 100,000 lbs at landing: would you feel more secure if they installed a landing-gear that can support 100,000 lbs or 125,000 lbs? What's the responsible and intelligent thing to do in these situations? The principle of 'good measure' is one that we constantly apply in our lives; I frankly don't see what's supposed to be so senseless about applying it to vitamins as well, especially in regard to vitamin C supplements which are virtually harmless and which only cost pennies. On that note, a monthly supply of vitamin C certainly doesn't cost $20-30 like you’re proclaiming: 120 capsules of 500mg roughly cost $6,00, which translates to $0,05/day or $1,50/month. Man, I'm trying to remain very polite because I usually appreciate your contributions on these forums, but if the only factual data which you're willing to share with us is that kind of extremely basic info, you might at least get it right and not exaggerate it by a factor of twentyfold.

Here's an excerpt from another survey similar to the one presented in my introduction. They did observe a decrease in deficiencies/inadequacies compared to previous years this time around, but here's to which factor they attributed that improvement:


Quote by ]Fruit and vegetable consumption among American adults remained relatively stable from 1994 through 2005 (55). For example, average daily fruit intake in persons ≥2 y of age remained the same from 1994–1996 to 1999–2002 (1.6 servings), and average vegetable consumption declined slightly from 3.4 to 3.2 servings/d during the same period (56). Increased intake of vitamin C–containing foods was unlikely to have contributed to the reduced prevalence of vitamin C deficiency during the recent survey.

(...)

In prosperous societies, supplement consumption has a significant effect on body stores and circulating concentrations of vitamin C. In NHANES 1999–2000, 52% of adults reported consumption of supplements in the past month, and 35% of adults were regular users of multivitamins (58). Usage rates in children were similar but lower in adolescents. These recent data show increased usage since the overall 40% usage reported during NHANES III (58) and are likely to explain in part the improved vitamin C status of the US population.

(...)

Adults who were nonusers of vitamin C supplements had a significantly higher prevalence of vitamin C deficiency than did users (Table 6).


Dietary changes didn't contribute to any improvements, while supplements significantly did. I'll be the first to concede that an overall shitty diet still isn't quite optimal in terms of health, but confronted to the distressing reality that most North Americans are so goddamn slow to get the memo, why exactly deprive lame people from their crutch?

Now let's depart all that boring crap about minimal doses of 90mg to counteract scurvy and let's get in the thick of the subject: optimal health. Read any scientific literature concerning vitamin C and you'll soon realize how broad its functions are in the human body. It plays a great role in the growth and repair of tissues in all parts of your body. It's needed for healing wounds and for repairing/maintaining bones and teeth. It's heavily implicated in collagen production, an important protein used to make skin, cartilage, tendons, ligaments, and blood vessels. It's required for the functioning of several enzymes and it's crucial for the immune system. It seems to be involved in the transfer of hydrogen atoms during cellular respiration. It's also an antioxidant, which inhibits the action of free radicals, which themselves can damage DNA, contribute to the aging process, and exacerbate the development of a plethora of health conditions. Dammit, I can't think of a single molecule which encompasses as many purposes in the human body as vitamin C does. And we're only just starting to understand its many functions, with the most recurrent themes of scientific papers being 'might also play a role in' and 'more research is needed'.

The shocking thing is that, by its very definition, the 90mg RDA of vitamin C was solely established to minimize signs of scurvy (read about it if you don't trust me); it doesn't account for all of the above for one fucking bit. And let's compare that ridiculous amount to what most animals are getting on a daily basis. You might be aware that humans are one of the very few animals which don't actually synthesize vitamin C inside their bodies; the near totality of them do. Comparatively speaking, in terms of weight, an adult goat of 150 lbs produces 2.5g of vitamin C on an average day, which is 25 times higher than what most people are getting with their pitiful modern diets. You might be tempted to think that the majority of that 2.5g is purely extraneous and isn't really utilized, but then you'd need to carefully explain why exactly a stressed/diseased goat actually ramps up its production of vitamin C to levels that are way beyond 10g/day.

If you want a comparison with an animal closer to us (which too doesn't synthesize vitamin C), I'd invite you to observe our dear cousin the chimpanzee: what are chimpanzees notorious for? Eating fruits, fruits and more fruits (ie. the highest source of vitamin C on Earth). Now I understand that a human isn't a goat isn't a chimpanzee (although we share 96% of our genes with the latter). But you have to admit that it's pretty damn curious that we'd only require 90mg of vitamin C for optimal health while just about any other animal on the planet naturally obtains amounts that are 25 to 100 times higher than that. And by extension, you might start to realize that ingesting 1g of vitamin C for health purposes really isn't as crazy or far-fetched as you might have first assumed.

How about a bit of history concerning vitamin C? It might not be known by the majority, but one of the very first proponents of high vitamin C in the 70s was Linus Pauling, one of the only four human beings to ever earn two Nobel prizes, and a man voted as the 16th most influential scientist in the whole fucking history of mankind. Francis Crick (who also earned a Nobel prize for discovering the DNA structure) even went so far as to dub him 'the father of molecular biology'. Now I don't encourage anybody to blindly follow his reasoning simply because of his stature. But by the same token, if you're tempted to rely on character assassination and present vitamin C advocates as mere delirious hippies to get your point across, I sincerely wish you the best of luck.

The great majority of studies regarding vitamin C were conducted in the 70s, shortly after Pauling published his hypotheses (which mostly concerned common colds at that time). For a while, many of them perfectly validated his theories:


Quote by [url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409678/
Vitamin C and Infections
]In the interval from 1972 to 1975, five placebo-controlled trials were published that used ≥2 g/day of vitamin C. Those five studies were published after Pauling’s book and therefore they formally tested Pauling’s hypothesis. A meta-analysis by Hemilä (1996) showed that there was very strong evidence from the five studies that colds were shorter or less severe in the vitamin C groups (p = 10−5), and therefore those studies corroborated Pauling’s hypothesis that vitamin C was indeed effective against colds [70].


And here are graphs extracted from two different studies of that era, which demonstrate the dose–response relationship between vitamin C and the duration of colds, and which both ultimately substantiate the exact same thing:




Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409678/


A few things to notice here. First, the impact of vitamin C increases linearly even for doses up to 8g/day, which completely disproves your view that anything beyond the minimal 0.09g RDA is completely wasted (although I'll address that much more in depth at a later point). Second, to reduce the duration of a cold by 1 day (ie. 20%), one would need to ingest above 5g/day of vitamin C year-round. With that in mind, expressing that 'vitamin C cures colds' isn't quite as fallacious as it is impractical for the majority of people, especially since getting 1/50th of that amount is still a challenge for plenty of them. Hence why vitamin C still isn't properly established as a 'reliable treatment' for colds by the medical community. But that certainly doesn't negate that vitamin C tremendously helps for fighting a wide variety of infectious diseases, or that 1g is significantly better at it than a ridiculous intake of 0.09g is.

Back to history. After all these positive observations, 3 influential journals published papers which surprisingly discredited all those findings. I'll just let H. Hemilä do the talking here, which is a leading expert on vitamin C who published the following scientific review just a year ago in 2017. This is a long quote, but it's absolutely worth reading it all:


Quote by ]Given the strong evidence from studies published before 1970 that vitamin C has beneficial effects against the common cold, and from the ≥2 g/day vitamin C studies published between 1972 and 1975 [70], it is puzzling that the interest in vitamin C and the common cold collapsed after 1975 so that few small trials on vitamin C and the common cold have been conducted thereafter (Figure 1).

This sudden loss of interest can be explained by the publication of the three highly important papers in 1975 (Figure 1). These papers are particularly influential because of their authors and the publication forums. Two of the papers were published in JAMA [72,73], and the third paper was published in the American Journal of Medicine [71]. Both of these journals are highly influential medical journals with extensive circulations. Two of the papers were authored by Thomas Chalmers [71,72], who was a highly respected and influential pioneer of RCTs [1,102,103], and the third paper was authored by Paul Meier [73], who was a highly influential statistician, e.g., one of the authors of the widely used Kaplan–Meier method [1,104,105].

Karlowski, Chalmers, et al. (1975) [72] published the results of a RCT in JAMA, in which 6 g/day of vitamin C significantly shortened the duration of colds (Figure 2A). However, these authors claimed that the observed benefit was not caused by the physiological effects of vitamin C, but by the placebo effect. However, the “placebo-effect explanation” was shown afterwards to be erroneous. For example, Karlowski et al. had excluded 42% of common cold episodes from the subgroup analysis that was the basis for their conclusion, without giving any explanation of why so many participants were excluded. The numerous problems of the placebo explanation are detailed in a critique by Hemilä [1,106,107]. Chalmers wrote a response [108], but did not answer the specific issues raised [109].

In the same year (1975), Chalmers published a review of the vitamin C and common cold studies. He pooled the results of seven studies and calculated that vitamin C would shorten colds only by 0.11 (SE 0.24) days [71]. Such a small difference has no clinical importance and the SE indicates that it is simply explained by random variation. However, there were errors in the extraction of data, studies that used very low doses of vitamin C (down to 0.025 g/day) were included, and there were errors in the calculations [1,110]. Pauling had proposed that vitamin C doses should be ≥1 g/day. When Hemilä and Herman (1995) included only those studies that had used ≥1 g/day of vitamin C and extracted data correctly, they calculated that colds were 0.93 (SE 0.22) days shorter, which is over eight times that calculated by Chalmers, and highly significant (p = 0.01) [110].

The third paper was a review published in JAMA by Michael Dykes and Paul Meier (1975). They analyzed selected studies and concluded that there was no convincing evidence that vitamin C has effects on colds [73]. However, they did not calculate the estimates of the effect nor any p-values, and many comments in their analysis were misleading. Pauling wrote a manuscript in which he commented upon the review by Dykes and Meier and submitted it to JAMA. Pauling stated afterwards that his paper was rejected even after he twice made revisions to meet the suggestions of the referees and the manuscript was finally published in a minor journal [111,112]. The rejection of Pauling’s papers was strange since the readers of JAMA were effectively prevented from seeing the other side of an important controversy. There were also other problems that were not pointed out by Pauling; see [1,70].

Although the three papers have serious biases, they have been used singly or in the combinations of two as references in nutritional recommendations, in medical textbooks, in texts on infectious diseases and on nutrition, when the authors claimed that vitamin C had been shown to be ineffective for colds [1] (pp. 21–23, 36–38, 42–45). The American Medical Association, for example, officially stated that “One of the most widely misused vitamins is ascorbic acid. There is no reliable evidence that large doses of ascorbic acid prevent colds or shorten their duration” [113], a statement that was based entirely on Chalmers’s 1975 review.

These three papers are the most manifest explanation for the collapse in the interest in vitamin C and the common cold after 1975, despite the strong evidence that had emerged by that time that ≥2 g/day vitamin C shortens and alleviates colds [70].


Done reading? In short, the few limited (yet highly influential) papers who proclaimed the ineffectiveness of vitamin C were ironically significantly more biased than the ones which they attempted to debunk. Actually, they did quite a bit more than 'attempting' to debunk the merits of vitamin C, since a lot of that crap slipped through and was taught to medical students/professionals for decades. Only today, the truth finally resurfaces and vitamin C is at last considered a lot more objectively.

Let's now address the myth that a high dose of vitamin C isn't utilized by the body and is instantly expelled through urine. Compare the respective effects of a 5g and 20g dose of ascorbic acid on blood plasma:



[url=https://www.livonlabs.com/proof/Dr_Hickey_Clinical_Study_Published.pdf]Source: https://www.livonlabs.com/proof/Dr_Hickey_Clinical_Study_Published.pdf



You can clearly see that even at such crazy high doses, an additional intake of vitamin C still produces an unmistakable raise in plasma concentration, for a duration of more than 8 hours. Yes, a certain portion of the dosage is lost fairly rapidly: for a dose 4 times higher than another one (as in the example above) a 100% absorption rate would result in a plasma concentration 4 times higher while it only doubled. At these megadoses, the estimated absorption rate is around 33%, which in this specific case will still result in a net additional 5g of vitamin C that's entirely available to your body for a greater part of the day when going from a dose of 5g to 20g (15g x 0.33 = 5g).

Here's the plasma concentration as function of dose for low-to-moderate intakes of vitamin C:



Source: https://pdfs.semanticscholar.org/5d5b/f096ec9591667f3ca9caab764defc95a08bd.pdf


As represented, someone who's timidly fidgeting around the current RDA will hardly ever have his/her plasma concentration of vitamin C at a level that's higher than 25uM a few sparse moments per day (and remember that 30-40% of people are still below that amount). Someone who ingests 500mg of vitamin C twice daily on the other hand (as I do myself), will show a concentration of 70uM year-fucking-round, nearly 24 hours a day. Taking into consideration the countless bodily functions of vitamin C and the many highly sensible health benefits associated with them, are you still so inclined to argue that vitamin C supplementation is completely futile? Besides, a multi-vitamin usually contains a low 60mg of vitamin C, which is roughly equivalent to an orange and which in itself still puts you below the RDA value. So yeah, adding a capsule of 500mg vitamin C on top of that is a perfectly valid habit to insure that you're getting a maximal (and optimal) plasma concentration.

Let me now explain why even the vitamin C that your body quickly rejects can still tremendously contribute to your health. What we commonly call 'vitamin C' actually represents two nearly identical molecules: ascorbic acid and dehydroascorbic acid. That's the reduced and oxidized form of vitamin C, respectively. Let's see who can spot the difference:




Left: Ascorbic Acid / Right: Dehydroascorbic Acid


Correct, dehydroascorbic acid is essentially ascorbic acid that has lost two Hydrogen atoms. It might not seem like much, and they do in fact share quite a few features (eg. much similar molar mass and both are equally efficient at fighting scurvy), but that propensity for ascorbic acid to donate two Hydrogen atoms is exactly what makes it such a great antioxidant. Whenever you hear that ascorbic acid is 'unstable' or 'oxidizes easily', it refers exactly to that feature, the ease with which it can donate Hydrogen atoms to other nearby molecules.

Let's now take as an example the hydroxyl radical, which is a free radical and an extremely common organic byproduct:

The red dot represented here indicates an unpaired electron (which is exactly what defines a free radical). Free radicals like this are extremely reactive and only exist transiently in nature, because electrons strive to be paired at all fucking cost. What happens when a free radical is present in a biological organism (or anywhere really) is that it will compulsively 'steal' electrons/atoms from surrounding molecules to pair that electron, thus damaging a great number of cellular structures (including DNA, which is suspected to cause cancer).

When ascorbic acid gets into the picture and freely donates Hydrogen atoms however, what will happen is this:


•OH + •H → H2O


That's right, instead of scavenging different parts of the cell, the free radicals will gladly accept the Hydrogen provided by ascorbic acid to form harmless H2O (ie. water).

Ascorbic acid really doesn't need a whole lot of time to oxidize and donate those Hydrogen atoms; remember that it's very unstable and will therefore perform this action at the mere presence of free radicals (which are pretty much everywhere in your body). So yes, at high doses, a certain amount of vitamin C will be urinated after only 30-60 minutes. However, a great percentage of that vitamin C is going to be dehydroascorbic acid which has already provided billions of Hydrogen atoms to your body and which already delivered its full antioxidant potential. Your body ingests a plethora of things, retains whatever it needs (however minimal such as inconspicuous Hydrogen atoms), and evacuates any wastes. I don't see you arguing that food is useless because we end up shitting (or breathing out) the near totality of it within a day, so why are you applying that logic to vitamin C?

Anyhow, that briefly summarizes the process that I went through when I decided to add vitamin C to my supplementation. If I didn't convince you of anything, at the very least you might start to realize that not every supplement user is an uninformed imbecile. And yes, I could justify any supplement that I presented on the previous page of this thread just as knowledgeably (although a few of them just make me cum a whole lot more, which is simply so tremendously fun).

But here, just because it's so goddamn easy to demonstrate the benefits of vitamin D supplementation on athletic performances:


Quote by ]In summary, we provide novel data demonstrating the spread of vitamin D concentrations in a large group of UK-based athletes tested in the winter months and report that 62% of our cohort could be described as vitamin D deficient. Our preliminary study suggests that 5000 IU per day of vitamin D3 supplementation for 8-weeks was associated with improved musculoskeletal performance as demonstrated through significant increases in vertical jump height, 10 m sprint times and a trend for improved bench press and back squat 1-RM.

Quote by [url=https://pdfs.semanticscholar.org/57da/cfbf71edfbb74b161c744027389bc65a52cf.pdf
Muscular effects of vitamin D in young athletes and non-athletes and in the elderly
]Vitamin D affects the diameter and number of type II, or fast twitch, muscle cells, and in particular that of type IIA cells. In severe vitamin D deficiency, proximal myopathy is observed characterized by type IIA cell atrophy. Vitamin D supplementation in young males increases the percentage of type IIA fibers in muscles, causing an increase in muscular high power output. Vitamin D-mediated induction of muscle protein synthesis and myogenesis results in muscles of higher quality and quantity, which is translated into increased muscle strength since there is a linear association between muscle mass and strength. Hypertrophy of type IIB muscle fibers results in enhanced neuromuscular performance. These types of fibers are major determinants of the explosive type of human strength that results in high power output.

Quote by [url=https://academic.oup.com/jcem/article/94/2/559/2598360
Vitamin D Status and Muscle Function in Post-Menarchal Adolescent Girls[/url]]We have used a novel outcome measure of JM to investigate how skeletal muscle function in the lower limb is affected by vitamin D and PTH status. Our data demonstrate that in a group of asymptomatic post-menarchal adolescents, serum 25(OH)D was positively related to muscle power, force, velocity, and jump height; PTH had a lesser effect upon muscle parameters. We have also confirmed the observations that there is an interdependence of muscle function (force and power) with anthropometric parameters; in our data this was predominantly weight (13, 17). Therefore, these data suggest that muscle contractility is affected by the girl’s vitamin D status, those with low-serum 25(OH)D concentration generated less power, and so jump height and velocity were lower than those with higher concentrations of 25(OH)D.
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Quote by SereneProdigy

Too much to post.


Congrats on your evidence based approach.

There is simply far too much to address so I'll pick out a few things.

1. RDA values are actually more than most people would ever need. The way that RDA values are calculated is that we look at the maximum that any human being would need...and then we add a bit. It's just a simplistic recommendation style to ensure that everyone gets enough no matter what their body size, condition etc.

2. Linus Pauling was a Nobel prize winning chemist, but as I recall his research was to do with ionic bonding. He didn't actually do any research with regards to ascorbic acid. His recommendations for taking massive doses of Vitamin C weren't based on any actual scientific research and have been disproved for decades.

3. If you post scientific papers, please include something from at least the last decade. I know that posting a bunch of antiquated articles may intimidate most people on this site, but I do research for a living.

If you are going to respond to me directly, please understand my background and respond accordingly. I don't need a crash course in the various effects of Vitamin C. I'm well aware of how antioxidants work. Posting a bunch of biochemical information just makes me roll my eyes and makes anyone else reading this completely zone out. I get that you want to seem smart, but I don't need a refresher course in 2nd year University biochemistry.

So vitamins work on an inverted U mechanism. This is nutrition 101.



So the Y axis is the amount of the nutrient and the x axis is performance of whatever function the nutrient is a factor in. There is an optimal amount that your body functions at. Not enough...function is diminished. Too much? Function is diminished.

An example I like to use is Vitamin A. If you don't have enough you get a condition called xeropthalmia. Your eyes dry out and you go blind. If you take in too much vitamin (in retinal form) you go blind as well. Now with fat soluble vitamins like A and D the inverted U graph is quite narrow. There is a small margin of error.

With water soluble vitamins like C and the Bs the graph is broad. So yes, there is very little chance of anyone getting toxicity from Vitamin C.

The big mistake people make is that they think that the more vitamin they take...the better the function. This is false. Think of it like a car. Your car needs an optimal level of gas to perform adequately. It doesn't make the car perform better if you start filling up the back seat with gasoline. I know this is simplistic, but it's an apt analogy.

Vitamin C has many functions, but the main one is acting as a coenzyme in collagen formation. It is a free ranging anti-oxidant as well. It has a noticeable effect in vitro, but the overall effects in the human body are much harder to determine. As far as I know most of the current research is investigating this aspect. The whole "Vitamin C cures colds" thing is pretty much laughed at though.

As for Vitamin D, that's a whole other thing. Completely different. There is an inert form of D in your subcutaneous tissue that is converted by UV rays into the active form of the vitamin. People living in northern regions don't get enough sunlight to produce enough, so nutritional intake is more important. Furthermore, vitamin D is fat soluble and acts more like a hormone,. If you want to discuss vitamin D, that's a whole different thread.

Now I gather from your posts, that you are a smart guy and you have a very scientific, analytical way of approaching things. I also gather that your background is not in biology or human physiology. The human body is more complicated than any machine. When looking for a cause-effect relationship there should ideally be both scientific evidence in an experimental sense and a valid theoretical mechanism for how the relationship takes place.

But now I ask you, have you looked at all the evidence and then come to a logical conclusion... Or are you starting with a preconceived opinion and now are looking for evidence to support that idea?

I apologize if I offended you. Feel free to eat as much vitamin C as you want. It won't hurt you.

And thank you for allowing me to talk about something other than guns or Trump. smile

PS: please make your next post shorter. I have OCD and the requirement to respond to everything is way too time consuming.
Cryptic Vigilante
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Quote by DamonX
A somehow reasonable response.


Let's first get the personal stuff out of the way…

Your previous posts neither offended me on a personal level nor challenged my lifestyle in any way, rest assured. However, witnessing a person propagating unsubstantiated absolutes while boasting to be 'the voice of science' kinda fucking irks me, yes. Please inform us how posturing on a textbook or whacking people with it was supposed to educate anybody about anything or assist them making healthy life decisions. You do realize that presenting the very first graph of my response and completely debunking your view that only derelict outcasts could possibly be lacking in vitamins probably took me less time than it took you to go hunting for a picture of your textbook, right? If you want us to compare the level of eye-rolling that we generate in one another, I regret to inform you that you have quite a lot to answer for yourself.

And please don't wave your diploma in front of me; your textbook didn't particularly impress me, I'm afraid that using the same tactic with a diploma isn't going to fly much higher on my end. I've encountered and debated with enough incompetent engineers, psychologists, doctors and scientists in my life to know full well that a diploma doesn't mean shit in and of itself. You seem like an intelligent person yourself and hopefully your diploma is being put to very good use in your daily life, but the merit which I’m willing to grant you in this thread stops right there. Ever heard of the saying 'show don't tell'? You certainly didn't show a whole lot knowledge prior to my intervention, so don't act so surprised when I feel like complementing my reasoning with a tiny bit of fundamental notions. Let us focus on our respective arguments and let's leave that unprofitable comparison of intellectual pedigrees out of the way, shall we?

In regard to whether or not I'm only supporting a preconceived opinion, I'll trust your deductive skills to figure that out. If you need a few hints, my 3rd and 4th listed interests on my profile were respectively 'nutrition' and 'science' when I was still displaying that information publicly. You currently can't see any of that yourself, but I can assure you that it's been that way even before I posted a single goddamn post on these forums. Between that, my analytical nature and my ability to extract relevant information from a plethora of studies, do I look like a guy who's never ever delved into any of that stuff prior to our trivial cyber-debate?

With that dealt with…

A lot of what you're expressing now actually substantiates my reasonable approach quite a lot more than it does your immodest original statements. My intake of vitamins might seem quite hefty to the uneducated eye, but the majority of it is in fact pretty damn moderate. Vitamin E is typically made available in tablets of 400 IU and yet I go through the hassle of buying α-tocopherol oil and carefully diluting it to only obtain a low 20 IU daily. Why? Because in the particular case of vitamin E, I really don't have the same evidence as I do with vitamin C that considerably going over the RDA provides any additional benefits. In fact, high doses of certain antioxidants are susceptible to strengthen cancerous cells just as much as healthy ones, and vitamin E has been shown to be particularly inclined to yield that detrimental effect at doses of 400 IU and higher. Just as I can debate that sticking to the RDA of 90mg isn't quite optimal regarding vitamin C, I'd vehemently argue that preserving an Upper Limit of 1,000 IU for vitamin E is largely irresponsible coming from the medical community.

I'd like to thank you though, for enlightening me about the obscure notion of 'too much of a good thing'. Just as I made you recollect your university lessons in biochemistry, you made me recall the 6-year-old memories shared with my mom when she comforted me after my overindulgence in Halloween candies made me feel a little dizzy. I guess that makes us even. I'd particularly like to offer my gratitude for including a random distribution curve to illustrate your point; the concept alone was a bit too elementary for my brain and the added picture really made me feel as if I was contemplating a deep scientific revelation.

Aside from that, the one and only reason why I cited a few studies concerning vitamin C and colds from the 70s is because the staggering majority of studies evaluating a great number of participants were conducted around that era. See for yourself:





If you're any involved in science, you know just as well as I do that the credibility of a paper is largely dependent upon the pool of available candidates, which actually makes those particular studies quite a bit more valid than most recent ones. Besides, that awfully common dismissive rationale only works within a few limited sets of circumstances. It's a splendid strategy to use in social sciences because 'societies' or 'demographics' are ever-changing entities. Care to inform us which major transformations affected the human body, ascorbic acid or the scientific culture in the last 50 years to completely invalidate such past data? And through which process exactly did studies from 1975 somehow lose their reliability along the way? Are you telling me that scientists should imperatively drop a bunch of apples on the ground just to see if the laws of Newton still apply after 400 years?

Anyway, to be perfectly honest I see the majority of your post as an opportunity to redeem yourself a little, which I'm definitely not going to interfere all that fervently with my typical exhaustivity. Just please don't post such bold yet empty statements in the future if you don't want me to rebuke or infantilize you like I did in this thread. I'm assuming that both of us have much better things to do, right?

And as demonstrated above, I can participate in a playful exchange of cyber-jabs just to make our predicament a bit more lively (which you particularly seem to be fond of yourself, haha), but please don't see me as a little butthurt idiot who's willing to make any of this more personal than it needs to be. I can genuinely say that you're one of the only rare persons in here which I can relate to and that singling you out like I did certainly wasn't done lightly. Just as frankly, the main reason why I didn't quite hold back with my criticism is because you've shown time and again on this website that you can handle it just fine, which actually puts you way beyond the majority of male Lushies in my esteem and which you'll hopefully take as a compliment.

Note: My sister is arriving tomorrow for a rare visit in town so I really won't be spending much time on the computer this weekend. If you somehow wish to continue this discussion any further, you'll have to wait a few days for my proper response.
Lurker
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Quote by SereneProdigy

Your previous posts neither offended me on a personal level nor challenged my lifestyle in any way, rest assured. However, witnessing a person propagating unsubstantiated absolutes while boasting to be 'the voice of science' kinda fucking irks me, yes.


By all means, please do look into the evidence. But look at everything. Not just the ones that suit your needs. After half a century of study, the general consensus is that vitamin c supplementation has no benefit whatsoever. Please consult with any Phd in nutrition or a registered dietitian. I think you'll have a hard time finding anyone who thinks that excessive vitamin C supplementation is beneficial. In fact, if anyone is suggesting that you take vitamin C as a daily supplement... they are probably trying to sell you vitamin C.

Quote by SereneProdigy

And please don't wave your diploma in front of me; your textbook didn't particularly impress me, I'm afraid that using the same tactic with a diploma isn't going to fly much higher on my end.


I wasn't waving anything in front of you. I was just surprised that you felt the need to present me with knowledge that you either didn't know I had...or you were just trying to present mass amounts of knowledge to the other people that might read these posts. If I was a dumb person, I would take offence, but really, I realize that you were just trying to impress the last remaining few that haven't been bored to death by your continuous misplaced essays. I would never assume to lecture you on engineering. Please accord me the equivalent professional courtesy when it comes to aspects of academic knowledge that I have education in.

Quote by SereneProdigy

In regard to whether or not I'm only supporting a preconceived opinion, I'll trust your deductive skills to figure that out. If you need a few hints, my 3rd and 4th listed interests on my profile were respectively 'nutrition' and 'science' when I was still displaying that information publicly. You currently can't see any of that yourself."


Well, then how would I know that? What a worthless thing to say. Come on guy...you're better than that. And if you have an interest in nutrition, but yet you haven't educated yourself with the basics.. something's wrong. The reason why I suggest people purchase an actual nutrition textbook is because it provides everyone with the basic knowledge that allows people to then pursue the field if they want.

How many casual internet websites can you find about engineering? How many casual websites are there about physics or mathematics? Very few. But...yet, you can google anything about nutrition that you want to find. Nutrition is a science, but yet every housewife out there thinks they know more that the people that devote their lives to that particular field.

And let's face it... the reason there are very few websites concerning math or physics is because nobody is making money of those fields. People make money of people's ignorance when it comes to health and nutrition.

Quote by SereneProdigy

A lot of what you're expressing now actually substantiates my reasonable approach quite a lot more than it does your immodest original statements. My intake of vitamins might seem quite hefty to the uneducated eye, but the majority of it is in fact pretty damn moderate.


I have no idea what your vitamin intake is. Whether or not it's beneficial is another discussion. I guess I'm just "uneducated" compared to you. I guess all the people that have devoted their lives to the study of nutrition are "uneducated" compared to you as well.

I'd like to thank you though, for enlightening me about the obscure notion of 'too much of a good thing'.

Quote by SereneProdigy


And... that's the problem right there isn't it? Vitamins are not a "good" thing. They are not magic beans. There are things we need. Beyond that those things are either harmful or irrelevant. Wait.. let me guess... you think that if you take lots of B vitamins, you will have super extra energy!!!

Quote by SereneProdigy

Aside from that, the one and only reason why I cited a few studies concerning vitamin C and colds from the 70s is because the staggering majority of studies evaluating a great number of participants were conducted around that era.


Correct. And why are those studies not still being held up as the be all and end all from vitamin C advocates? Because in science, results have to be recreated in various populations to be deemed valid. You can't just cherry-pick some bullshit study from 50 years ago and use that as a basis for nutrient recommendations. Which is why every scientist in the world agrees that excessive vitamin C intake is worthless. If you want to use scientific evidence as an argument you need to look at systematic reviews or meta analysis. Any ridiculous theory has some ancient half-assed study to support it. As the highest level of statistical evidence, we evaluate every study, do a statistical regression analysis and make an informed recommendation based on the findings.

In 50 years, the finding are that... well you know.

I would never suggest that you accept everything I say. I am an expert in a field just like you are an expert in yours. I have a lot of education in nutrition, but it's not my area of expertise. By all means learn all you can if you are interested in the field. The fact that you would discount a university text book, (which is essentially the accumulation of thousands of people's knowledge and a hundred years of study) is a bit disconcerting.

And by the way... if you are really concerned about antioxidants, maybe do some research into the effect of smoking on oxidative effects on the human body. I'm pretty sure that you'll find that smoking cessation has a much more proven track record on anti-oxidation than spending 30 bucks month on orange flavoured pills.

This has been another episode of:

Lurker
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Quote by trinket

A Multivitamin and Vit D, which my general practitioner suggested I take.



Wow. Did your GP get his/her degree from "Cover your own ass University?"

No folate? You must be older than I thought.

You should go back and ask about clozapine, risperidone, and probably some citalopram.
Convict
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Quote by DamonX


Wow. Did your GP get his/her degree from "Cover your own ass University?"

No folate? You must be older than I thought.

You should go back and ask about clozapine, risperidone, and probably some citalopram.


Well, I can’t post anywhere on the forums without you being an asshole and giving a shitty response to most of my forum posts. Your post to me added nothing of value to the thread whatsoever. When people post on these forums they don’t do so to provide you with fodder for your deranged sense of humour. I’m flattered you find my posts so interesting but you know, I wish someone would tell you to fuck off. Stop and think for a minute, what other reasons for not requiring extra folate there might be for a woman of 33 who has no children. The greatest disappointment of my life.

There are a lot of members here who suffer from various forms of mental illness. Some people find it extremely difficult to open up about how it affects them but once encouraged, do so. This often makes them realise they aren’t alone. aren’t we supposed to encourage and support those people? You think nothing of making fun of the subject. That disgusts me. I’m pretty sure that qualifies you for a Masters in how to be a cunt. You’ve called me crazy and psychotic in the past. Don’t you think it’s an insult to those who suffer mental illness, to joke about it? You obviously don’t think about what you write before you write it. Or maybe you do so as to get maximum emotional response to your provocations. Nothing seems to be off limits for you. Have you ever thought about pretending to be a decent human being and just being nice to people? You might even like it.

I’m not going to stop posting on these forums just because your stupid ass trolls me so it would be great if you would leave me the fuck alone when I post. Do you realise that every time you post your sick shit that you show everyone a little more of the nasty person you are. I don’t know anyone who thinks you’re funny.